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Permeability Of Hydrophilic
Part I of Essay
SUMMARY
Investigations of the integrity and transport characteristics of 2/4/A1 cells
have been done in this report. The cell line was isolated from rat fetal
intestinal epithelial cells and transfected with thermolabile SV40 large T
antigen.
These cells proliferated at 33 .... Part II of Essay
.... monolayers selectively restricted the permeation of hydrophilic
permeability markers proportional to molecular weight and discriminated more
accurately between the molecules of intermediate molecular weight compared to
Caco-2 cells.
These results indicated that 2/4/A1 cells could be used as a model for
hydrophilic drug absorption.
INTRODUCTION
The small intestine plays a crucial role in the absorption of drugs and
nutrients. Exogenous substances cross a series of barriers during the process
of intestinal absorption: (1) the aqueous bou ....
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Words: 2422 - Pages: 9
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